Utility
The Ford F-250 will most certainly prove more practical than the Tacoma for those of you with frequent kid-cargo.
The Ford F-250 is a better choice than the Toyota regarding transporting cargo, especially if you frequently need to carry a lot of cargo or big animals.
The Ford outpulls the Toyota by a large margin.
Performance
As far as horsepower, the Ford F-250 packs quite a wallop and will knock the Toyota Tacoma down a few rungs. On the other hand, remember that high horsepower engines often command higher insurance premiums.
With that kind of horsepower, the Ford F-250 is a true speedster.
Dimensions
The Ford F-250 is tremendously heavier than the Toyota Tacoma.
Your wallet will hurt more every time you fill up the Ford F-250 than the Toyota Tacoma because of its bigger tank.
The Toyota Tacoma fits in smaller parking spaces than the Ford F-250.
The F-250's longer wheelbase will result in a smoother, more stable ride; on the flip side, the Toyota Tacoma may give a more agile feel in daily traffic.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Toyota is considerably cheaper to get to the dealership than the Ford F-250.
The Ford is tremendously pricier than the Toyota when it comes to MSRP.
Handling
With its tighter turning radius, the Toyota Tacoma is most certainly nimbler than the Ford F-250, something to consider if you do a lot of city driving; however, bear in mind that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The Ford's engine is tremendously larger than the Toyota Tacoma's. Note that bigger engines may use more gas than smaller ones.
The Ford F-250 packs quite a punch compared to the Toyota Tacoma in terms of torque, which is roughly equivalent to acceleration.
Comfort
Taller drivers will significantly enjoy the extra head room in the F-250's front cabin compared to the Toyota Tacoma.
The ampler interior dimensions of the Ford make it substantially more spacious for your passengers than the Toyota.
Warranty
The Ford and the Tacoma have the same basic warranty.