Utility
The Toyota will most definitely prove handier than the E-350 Super Duty for those of you with frequent child-cargo.
The Ford E-350 Super Duty is a better choice than the Toyota Sienna regarding hauling capacity, especially if you often need to carry a lot of stuff or massive pets.
Towing is considerably more the Ford E-350 Super Duty's forte than it is the Toyota's.
Dimensions
The Ford is substantially more bulky than the Toyota Sienna.
Your wallet will hurt more every time you fill up the Ford E-350 Super Duty than the Toyota Sienna because of its larger tank.
The Toyota Sienna and the Ford E-350 Super Duty compete for the same parking spaces.
The E-350 Super Duty's longer wheelbase will result in a smoother, more stable ride; on the flip side, the Toyota may give a nimbler feel in daily traffic.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Toyota Sienna is substantially cheaper to get to the dealership than the Ford E-350 Super Duty.
The Ford isn't much more expensive than the Sienna regarding MSRP.
Handling
With its tighter turning circle, the Toyota Sienna is most certainly more maneuverable than the Ford E-350 Super Duty, something to consider if you do a lot of city driving; however, keep in mind that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The Ford E-350 Super Duty has a bigger engine than the Toyota Sienna. Remember that smaller engines typically get better gas mileage, but smaller engines can be stressed more.
The Ford E-350 Super Duty packs quite a wallop compared to the Toyota Sienna in terms of torque, which is the force that lets you accelerate quickly.
Torque equals pickup, and the Ford E-350 Super Duty will have picked up and gone by the time the Toyota Sienna finally gets moving.
Comfort
While the rear of the Toyota Sienna offers a bit more head- and leg-room than the Ford, there honestly isn't much of a difference.
Warranty
The Ford and the Toyota have the same basic warranty.