Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Toyota Sienna is substantially cheaper to get to the dealership than the Ford E-250.
When it comes to MSRP, the Toyota Sienna costs approximately as much as the Ford E-250 (though the Ford E-250 is a bit cheaper).
Utility
The Toyota Sienna will most definitely prove more convenient than the Ford E-250 for those of you with frequent child-cargo.
The Ford E-250 is a better choice than the Toyota Sienna when it comes to transporting cargo, especially if you frequently need to carry a lot of stuff or sizeable pets.
The E-250 outpulls the Toyota Sienna by a massive margin.
Comfort
While the rear of the Toyota Sienna offers a bit more head- and leg-room than the Ford E-250, there frankly isn't much of a difference.
Dimensions
The E-250 is considerably more bulky than the Toyota.
Your wallet will hurt more every time you fill up the Ford E-250 than the Toyota Sienna because of its larger tank.
The Toyota Sienna and the Ford E-250 compete for the same parking spaces.
The Toyota Sienna's shorter wheelbase will give a sprier feel in daily traffic. On the other hand, the Ford E-250 is likely to have a smoother, more stable ride.
Handling
With its tighter turning circle, the Toyota Sienna is quite certainly more maneuverable than the E-250, something to consider if you do a lot of city driving; on the flip side, note that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The Ford E-250's engine is significantly more sizeable than the Toyota's. Note that larger engines may use more gasoline than smaller ones.
The Toyota Sienna could learn a lesson or two from the Ford E-250 in terms of pickup.
Warranty
The Ford and the Toyota Sienna have the same basic warranty.