Utility
Drivers with frequent kid-duty might favor the Ford over the Toyota Sienna.
The Ford E-150 is a better choice than the Toyota Sienna when it comes to hauling capacity, especially if you often need to carry a lot of luggage or sizeable pets.
Towing is considerably more the Ford E-150's forte than it is the Toyota Sienna's.
Dimensions
The E-150 is significantly heavier than the Sienna.
Your wallet will hurt more every time you fill up the Ford E-150 than the Sienna because of its larger tank.
The Sienna and the Ford E-150 compete for the same parking spaces.
The Ford E-150's longer wheelbase will likely result in a smoother, more stable ride; on the flip side, the Toyota Sienna may give a nimbler feel in daily traffic.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Toyota is substantially cheaper to get to the dealership than the Ford.
The Toyota Sienna isn't much more expensive than the Ford E-150 in terms of MSRP.
Handling
With its tighter turning circle, the Toyota Sienna is definitely sprier than the Ford E-150, something to consider if you do a lot of city driving; on the other hand, note that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The Ford's engine is significantly more sizeable than the Toyota Sienna's. Bear in mind that more massive engines may use more gasoline than smaller ones.
The Toyota Sienna could learn a lesson or two from the Ford E-150 when it comes to torque.
Comfort
The Toyota Sienna is not particularly roomier for your passengers than the Ford E-150.
Warranty
The Ford E-150 and the Toyota have the same basic after-sale protection.