Utility
The Toyota Sequoia is a better choice than the Lexus when it comes to hauling capacity, especially if you frequently need to carry a lot of equipment or big dogs.
Drivers with frequent child-duty might favor the Toyota Sequoia over the Lexus RX 350.
The Sequoia outpulls the Lexus RX 350 by a large margin.
Dimensions
The Toyota Sequoia is considerably more ponderous than the RX 350.
Your wallet will hurt more every time you fill up the Toyota Sequoia than the Lexus RX 350 because of its bigger tank.
The Toyota Sequoia rides lower than the Lexus, which is a good thing for its center of gravity and ease of access.
The RX 350 and the Toyota Sequoia compete for the same parking spaces.
The Toyota Sequoia's longer wheelbase will result in a smoother, more stable ride; on the other hand, the RX 350 may give a sprier feel in daily traffic.
Convenience
You most definitely won't have to visit your friendly gas station more often with the Lexus than with the Toyota Sequoia, as both offer comparable ranges.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. It costs approximately the same to get the Toyota Sequoia to the dealership as the Lexus RX 350.
Producing a precise fuel economy evaluation is so hard that some think not even the federal government can do it, but it looks as though the Lexus RX 350 is the winner regarding fuel economy.
With respect to fuel economy, the Lexus RX 350 beats the Toyota Sequoia.
In terms of MSRP, the Toyota Sequoia costs approximately as much as the Lexus (though the Lexus is a tad cheaper).
The Toyota Sequoia will cost you a bundle in gasoline every year compared to the RX 350.
Handling
The Toyota Sequoia has substantially wider tires than the Lexus RX 350. Note that wider tires can improve handling, while smaller tires could provide better handling in deep snow.
With its tighter turning circle, the Lexus RX 350 is quite certainly sprier than the Toyota Sequoia, something to consider if you do a lot of city driving; on the flip side, remember that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The Toyota Sequoia has a larger engine than the Lexus RX 350. Keep in mind that smaller engines are often cheaper to fix, but smaller engines can be stressed more.
The Lexus RX 350 could learn a lesson or two from the Toyota Sequoia with respect to pickup.
The Toyota Sequoia packs quite a punch compared to the Lexus in terms of torque, which is roughly equivalent to acceleration.
Comfort
Taller drivers will substantially enjoy the extra head room in the Toyota Sequoia's front cabin compared to the Lexus RX 350.
The Toyota offers more head- and leg-room to your passengers than the Lexus RX 350 does.
Overview
The basic after-sale protection that comes with the Sequoia isn't quite as generous as the Lexus RX 350's.