Utility
Neither the Toyota Avalon nor the Lexus HS 250h has a marked advantage as far as seating capacity.
Performance
With respect to horsepower, the Avalon packs quite a punch and will knock the Lexus HS 250h down a few rungs. On the other hand, keep in mind that high horsepower engines often command higher insurance premiums.
Dimensions
Your wallet will hurt more every time you fill up the Toyota than the Lexus HS 250h because of its bigger tank.
The Lexus HS 250h and the Avalon compete for the same parking spaces.
Convenience
You will have to visit your friendly gas station more often with the Toyota than with the HS 250h.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Toyota Avalon is significantly cheaper to get to the dealership than the Lexus.
Producing a precise gas mileage evaluation is so tough that some think not even the federal government can do it, but it looks as though the Lexus HS 250h is the winner in terms of fuel economy.
In terms of MSRP, the HS 250h costs significantly more than the Toyota Avalon.
The Lexus HS 250h will save you a lots_of_money at the pump every year compared to the Toyota Avalon.
Handling
With their comparable turning circles, the Toyota and the Lexus HS 250h most definitely handle about the same into and out of tight spots.
Drivetrain
The Lexus HS 250h's engine is significantly smaller than the Avalon's. Keep in mind that smaller engines can be stressed more; however, smaller engines typically get better gas mileage.
The Lexus could learn a lesson or two from the Toyota Avalon with respect to torque.
The Avalon packs quite a punch compared to the Lexus HS 250h with respect to torque, which is roughly equivalent to acceleration.
Comfort
While the front cabin in the Toyota Avalon offers a bit more head room than the Lexus, there honestly isn't much of a difference.
The ampler interior dimensions of the Toyota make it more spacious for your passengers than the Lexus.
Warranty
The basic after-sale protection that comes with the Avalon isn't quite as generous as the Lexus HS 250h's.