Handling
The Toyota 4Runner has markedly wider tires than the Nissan Murano. Keep in mind that bigger tires might improve handling, while narrower tires could improve gas mileage.
Drivetrain
The Murano's engine is substantially smaller than the 4Runner's. Note that smaller engines can be stressed more; on the other hand, smaller engines are often cheaper to fix.
Torque is roughly equivalent to acceleration, and in this respect, the Toyota 4Runner isn't much more powerful than the Murano.
The Nissan Murano has no lessons to learn in terms of torque from the Toyota 4Runner.
Utility
The 4Runner will very likely prove handier than the Nissan Murano for those of you with frequent child-cargo.
The Toyota 4Runner outpulls the Nissan Murano by a large margin.
Convenience
The Toyota 4Runner's fuel tank will need to be replenished a little more often than the unit in the Nissan Murano.
Comfort
While the front cabin in the Murano offers a bit more head room than the Toyota 4Runner, there frankly isn't much of a difference.
The Nissan provides more head- and leg-room to your passengers than the Toyota 4Runner does.
Dimensions
The Nissan Murano's tank is approximately the same size as the Toyota 4Runner's, though the Toyota 4Runner's is a bit bigger.
The Toyota 4Runner rides lower than the Nissan Murano, which is a good thing for its center of gravity and ease of access.
The Nissan Murano and the 4Runner compete for the same parking spaces.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. It costs about the same to get the Toyota 4Runner to the dealership as the Nissan Murano.
Regarding gas mileage, the Nissan Murano has the Toyota beat.
Regarding gas mileage, the Nissan bests the 4Runner.
Regarding MSRP, the Toyota 4Runner costs approximately as much as the Nissan Murano (though the Nissan Murano is slightly cheaper).
Overview
The Nissan Murano and the Toyota have the same basic warranty.