Handling
With their similar turning circles, the Toyota 4Runner and the Lexus RX 350 quite certainly handle approximately the same into and out of tight spots.
Drivetrain
The Lexus RX 350's engine is substantially smaller than the Toyota 4Runner's. Bear in mind that smaller engines can be stressed more; on the flip side, smaller engines are often cheaper to fix.
Torque is roughly equivalent to acceleration, and in this respect, the Toyota 4Runner isn't much more powerful than the Lexus RX 350.
Utility
Neither the Toyota nor the Lexus has a marked advantage in terms of seating capacity.
Towing is significantly more the Toyota's forte than it is the Lexus RX 350's.
Convenience
The Lexus RX 350's fuel tank will need to be replenished more often than the unit in the Toyota 4Runner.
Comfort
While the front cabin in the Toyota 4Runner offers a bit more head room than the Lexus RX 350, there frankly isn't much of a difference.
The Lexus RX 350 provides more head- and leg-room to your passengers than the Toyota does.
Dimensions
Your wallet will hurt more every time you fill up the Toyota 4Runner than the Lexus RX 350 because of its larger tank.
The Lexus RX 350 and the Toyota 4Runner compete for the same parking spaces.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. It costs approximately the same to get the Toyota 4Runner to the dealership as the Lexus RX 350.
As far as gas mileage, the Lexus RX 350 is slightly better than the Toyota, but not by much.
The Toyota 4Runner doesn't pale in comparison to the Lexus RX 350 regarding fuel economy.
The Lexus isn't much pricier than the 4Runner as far as MSRP.
Warranty
The basic after-sale protection that comes with the Toyota 4Runner isn't quite as generous as the Lexus RX 350's.