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Comfort
Rear passengers will be able to stretch out a lot more in the Acura MDX than in the Lexus RX 350.
The Lexus RX 350 will be a hit with tall drivers and their front seat passengers, since it has greater front head- and legroom than the Acura MDX.
Convenience
You'll be making about the same number of stops at the gas station with the Acura MDX as you will with the Lexus RX 350, as they are both able to travel similar distances on a tank of gas.
Cost
There are a lot of factors to consider when calculating the overall cost of a vehicle. The main consideration is Manufacturer's Suggested Retail Price (MSRP). The Acura MDX is somewhat more expensive than the Lexus RX 350.
Another consideration is the Destination Charge, which is a standard charge for transporting the vehicle to the dealer from where it's built. Both the Acura MDX and the Lexus RX 350 have similar Destination Charges.
Dimensions
Since the Acura MDX is much wider than the Lexus RX 350, finding a wide enough spot in a parking lot may be a bit more challenging.
When looking at overall length, the Acura MDX takes up about the same amount of space in your garage as the Lexus RX 350.
Drivetrain
With somewhat higher torque, the Acura MDX transmits power to its wheels a bit more effectively than the Lexus RX 350.
Handling
The Acura MDX has a smaller turning radius than the Lexus RX 350, allowing you to more easily maneuver in and out of tight spots.
Performance
When considering towing capacity, the Acura MDX is clearly the choice over the Lexus RX 350 for pulling heavy loads.
The Acura MDX has a little more horsepower than the Lexus RX 350.
Utility
The Acura MDX offers greater seating capacity than the Lexus RX 350, making it a better choice for those who find themselves chauffeuring others around.
You'll be able to fit about the same amount of groceries in the Acura MDX as you will in the Lexus RX 350.
Warranty
The Acura MDX comes with essentially the same basic warranty as the Lexus RX 350.
Compare the 2012 Acura MDX and the 2012 Lexus RX 350. 
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2012 Acura
|
2012 Lexus
|
| Cash Back Rebate: | Up to $1,500 | Visit Rebate Center |
| Low APR Loan: | As low as 0.90% | -- |
| Lease Incentive: | As low as 1.92% | As low as 1.44% |
| City MPG: | 16 | 18 |
| Highway MPG: | 21 | 24 - 25 |
| Engine(s): | V-6 | V-6 |
| Seating Capacity: | 7 - 7 | 5 - 5 |
| Basic Warranty: | 4 years/50,000 miles | 4 years/50,000 miles |
Safety Rating: Front 
Vehicle safety data is provided by IIHS, the Insurance Institute for Highway Safety, an independent, nonprofit, scientific, and educational organization dedicated to reducing deaths and injuries on the nation's highways.
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Good | Good |
| Safety Rating: Side
Vehicle safety data is provided by IIHS, the Insurance Institute for Highway Safety, an independent, nonprofit, scientific, and educational organization dedicated to reducing deaths and injuries on the nation's highways.
|
Good | Good |
| Safety Rating: Rear
Vehicle safety data is provided by IIHS, the Insurance Institute for Highway Safety, an independent, nonprofit, scientific, and educational organization dedicated to reducing deaths and injuries on the nation's highways.
|
Good | Good |
| Invoice*: | $39,863 - $48,672 | $36,537 - $37,846 |
Days on Lot measures the average number of days a model sits on a dealer's lot before it's sold. This is one predictor of a dealer's willingness to negotiate.
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