Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Titan is considerably cheaper to get to the dealership than the GMC Sierra 2500HD.
In terms of MSRP, the GMC Sierra 2500HD costs almost as much as the Nissan Titan (though the Nissan Titan is a bit cheaper).
Utility
The Sierra 2500HD and the Titan can accommodate the same number of passengers.
The GMC Sierra 2500HD is likely a better choice than the Nissan Titan as far as transporting cargo, especially if you frequently need to carry a lot of stuff or large dogs.
Towing is considerably more the GMC Sierra 2500HD's forte than it is the Titan's.
Comfort
While the front cabin in the GMC Sierra 2500HD offers a bit more head room than the Nissan Titan, there honestly isn't much of a difference.
The GMC Sierra 2500HD is not particularly roomier for your passengers than the Titan.
Dimensions
The GMC Sierra 2500HD is significantly more bulky than the Nissan Titan.
The GMC Sierra 2500HD's tank is roughly the same size as the Nissan Titan's, though the Nissan Titan's is a tad larger.
The Nissan Titan and the GMC Sierra 2500HD compete for the same parking spaces.
Handling
With their similar turning circles, the GMC Sierra 2500HD and the Nissan Titan quite certainly handle about the same into and out of tight spots.
Drivetrain
The Nissan Titan's engine is a little smaller than the GMC Sierra 2500HD's, but not terribly so.
Torque equals pickup, and the GMC Sierra 2500HD will have picked up and gone by the time the Nissan Titan finally gets moving.
Torque is roughly equivalent to acceleration, and in this respect, the GMC Sierra 2500HD is tremendously more powerful than the Nissan Titan.
Warranty
The Nissan and the GMC Sierra 2500HD have the same basic warranty.