Utility
Neither the Ford F-350 nor the Nissan has a marked advantage as far as seating capacity.
The F-350 is likely a better choice than the Titan with respect to hauling capacity, especially if you often need to carry a lot of equipment or massive animals.
Towing is considerably more the Ford F-350's forte than it is the Nissan Titan's.
Performance
With that kind of horsepower, both the F-350 and the Nissan Titan are genuine sportscars.
Dimensions
The Ford F-350 is considerably heavier than the Nissan Titan.
The Nissan Titan's tank is roughly the same size as the Ford F-350's, though the Ford F-350's is somewhat larger.
The Nissan Titan and the Ford F-350 compete for the same parking spaces.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Nissan Titan is considerably cheaper to get to the dealership than the Ford F-350.
The Ford F-350 is substantially pricier than the Nissan Titan regarding MSRP.
Handling
With their similar turning radii, the Nissan Titan and the Ford F-350 most definitely handle approximately the same into and out of tight spots.
Drivetrain
The Ford F-350's engine is a bit smaller than the Nissan Titan's, but not terribly so.
The Ford F-350 has no lessons to learn with respect to pickup from the Nissan Titan.
Comfort
While the front cabin in the Ford F-350 offers a bit more head room than the Nissan Titan, there really isn't much of a difference.
The Nissan is not particularly more spacious for your passengers than the Ford F-350.
Warranty
The Nissan Titan and the Ford F-350 have the same basic after-sale protection.