Utility
Drivers with frequent child-duty might favor the Quest over the Ford E-250.
The Ford E-250 is a better choice than the Nissan Quest regarding hauling capacity, especially if you frequently need to carry a lot of stuff or big animals.
Towing is considerably more the Ford E-250's forte than it is the Nissan Quest's.
Dimensions
The E-250 is substantially more bulky than the Nissan Quest.
Your wallet will hurt more every time you fill up the Ford E-250 than the Nissan Quest because of its bigger tank.
The Nissan and the E-250 compete for the same parking spaces.
The Quest's shorter wheelbase may produce a less-settled highway ride but a more maneuverable feel in daily traffic than the Ford E-250.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Nissan Quest is considerably cheaper to get to the dealership than the Ford E-250.
As far as MSRP, the Quest costs roughly as much as the E-250 (though the E-250 is somewhat cheaper).
Handling
With its tighter turning circle, the Nissan Quest is quite certainly nimbler than the Ford E-250, something to consider if you do a lot of city driving; on the other hand, remember that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The E-250's engine is substantially more sizeable than the Nissan Quest's. Note that larger engines may use more gas than smaller ones.
Torque is the force that lets you accelerate quickly, and in this respect, the Ford E-250 is significantly more powerful than the Nissan Quest.
The Quest could learn a lesson or two from the Ford E-250 in terms of torque.
Comfort
While the front cabin in the E-250 offers a bit more head room than the Nissan Quest, there really isn't much of a difference.
The ampler interior dimensions of the Nissan Quest make it significantly roomier for your passengers than the Ford E-250.
Warranty
The Ford E-250 and the Nissan Quest have the same basic warranty.