Utility
Drivers with frequent child-duty might favor the Ford E-150 over the Nissan Quest.
The Ford E-150 is a better choice than the Nissan with respect to hauling capacity, especially if you frequently need to carry a lot of luggage or sizeable pets.
Towing is substantially more the Ford E-150's forte than it is the Nissan's.
Dimensions
The Ford E-150 is significantly more bulky than the Nissan Quest.
Your wallet will hurt more every time you fill up the Ford E-150 than the Nissan Quest because of its bigger tank.
The Nissan Quest and the Ford E-150 compete for the same parking spaces.
The Ford's longer wheelbase will result in a smoother, more stable ride; on the other hand, the Quest may give a nimbler feel in daily traffic.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Quest is substantially cheaper to get to the dealership than the Ford E-150.
The Quest is substantially pricier than the Ford E-150 in terms of MSRP.
Handling
With its tighter turning radius, the Quest is quite certainly nimbler than the Ford E-150, something to consider if you do a lot of city driving; however, bear in mind that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The E-150's engine is considerably more sizeable than the Quest's. Bear in mind that larger engines may use more gasoline than smaller ones.
The Nissan Quest could learn a lesson or two from the Ford E-150 with respect to pickup.
Torque equals pickup, and the Ford E-150 will have picked up and gone by the time the Nissan finally gets moving.
Comfort
While the front cabin in the Ford E-150 offers a bit more head room than the Nissan Quest, there honestly isn't much of a difference.
The ampler interior dimensions of the Nissan Quest make it considerably more spacious for your passengers than the Ford E-150.
Warranty
The Ford E-150 and the Nissan Quest have the same basic warranty.