Utility
Drivers with frequent child-duty might favor the Chevrolet over the Nissan Quest.
The Chevrolet is likely a better choice than the Nissan with respect to hauling capacity, especially if you frequently need to carry a lot of loot or big animals.
The Chevrolet Express 2500 outpulls the Quest by a large margin.
Performance
With that kind of horsepower, the Chevrolet Express 2500 is a genuine speedster.
Dimensions
The Chevrolet Express 2500 is significantly more bulky than the Nissan.
Your wallet will hurt more every time you fill up the Chevrolet Express 2500 than the Quest because of its larger tank.
The Nissan and the Chevrolet Express 2500 compete for the same parking spaces.
The Chevrolet Express 2500's longer wheelbase will result in a smoother, more stable ride; on the flip side, the Nissan Quest may give a sprier feel in daily traffic.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Nissan Quest is significantly cheaper to get to the dealership than the Express 2500.
The Nissan Quest isn't much costlier than the Express 2500 regarding MSRP.
Handling
With its tighter turning radius, the Nissan Quest is most certainly nimbler than the Express 2500, something to consider if you do a lot of city driving; on the other hand, note that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The Nissan's engine is tremendously smaller than the Chevrolet's. Remember that a smaller engine usually has to work a little harder; however, smaller engines are often cheaper to fix.
Torque equals pickup, and the Chevrolet Express 2500 will have picked up and gone by the time the Nissan finally gets moving.
Torque is the force that lets you accelerate quickly, and in this respect, the Express 2500 is tremendously more powerful than the Nissan Quest.
Comfort
Taller drivers will significantly enjoy the extra head room in the Nissan's front cabin compared to the Chevrolet.
The Quest provides more head- and leg-room to your passengers than the Express 2500 does.
Warranty
The Chevrolet Express 2500 and the Nissan Quest have the same basic warranty.