Utility
The Toyota 4Runner will very likely prove handier than the Nissan Murano for those of you with frequent child-cargo.
Towing is quite a bit more the Toyota 4Runner's forte than it is the Nissan Murano's.
Dimensions
The Nissan Murano's tank is approximately the same size as the 4Runner's, though the Toyota 4Runner's is a little larger.
The 4Runner rides lower than the Nissan Murano, which is a good thing for its center of gravity and ease of access.
The Nissan Murano and the Toyota 4Runner compete for the same parking spaces.
Convenience
You quite certainly won't have to visit your friendly gas station more often with the 4Runner than with the Nissan Murano, as both offer comparable mileage ranges.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. It costs about the same to get the Toyota 4Runner to the dealership as the Murano.
As far as fuel economy, the Nissan has the 4Runner beat.
The Toyota 4Runner pales in comparison to the Murano when it comes to fuel economy.
The Nissan Murano isn't much less expensive than the Toyota 4Runner in terms of MSRP.
Handling
The Toyota 4Runner has markedly wider tires than the Nissan Murano. Keep in mind that wider tires could improve handling, while smaller tires may improve gas mileage.
Drivetrain
The Toyota has a bigger engine than the Nissan Murano. Keep in mind that smaller engines are often cheaper to fix, but smaller engines can be stressed more.
The Murano has no lessons to learn in terms of torque from the Toyota 4Runner.
Comfort
While the front cabin in the Nissan Murano offers a bit more head room than the Toyota 4Runner, there really isn't much of a difference.
The Nissan Murano provides more head- and leg-room to your passengers than the Toyota does.
Overview
The Toyota 4Runner and the Nissan have the same basic after-sale protection.