Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Frontier is considerably cheaper to get to the dealership than the Ford F-250.
The Nissan Frontier is considerably less costly than the Ford F-250 in terms of MSRP.
Utility
The Ford F-250 is a better choice than the Nissan Frontier in terms of transporting cargo, especially if you frequently need to carry a lot of loot or sizeable pets.
The Ford F-250 will most certainly prove more practical than the Nissan Frontier for those of you with frequent child-cargo.
The Ford outpulls the Frontier by a massive margin.
Comfort
Taller drivers will substantially enjoy the extra head room in the F-250's front cabin compared to the Nissan Frontier.
The ampler interior dimensions of the Ford F-250 make it significantly roomier for your passengers than the Nissan Frontier.
Dimensions
The Ford F-250 is tremendously heavier than the Nissan Frontier.
Your wallet will hurt more every time you fill up the F-250 than the Nissan Frontier because of its bigger tank.
The Frontier and the Ford F-250 compete for the same parking spaces.
The Frontier's shorter wheelbase will likely give a nimbler feel in daily traffic. On the flip side, the Ford F-250 is likely to have a smoother, more stable ride.
Performance
As far as horsepower, the Ford F-250 packs quite a wallop and will knock the Nissan Frontier down a few rungs. However, keep in mind that high horsepower engines often command higher insurance premiums.
Handling
With its tighter turning radius, the Frontier is definitely nimbler than the Ford F-250, something to consider if you do a lot of city driving; on the other hand, remember that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The Ford F-250 has a more sizeable engine than the Nissan. Remember that smaller engines typically get better gas mileage, but smaller engines can be stressed more.
The Nissan Frontier could learn a lesson or two from the Ford F-250 in terms of torque.
Warranty
The F-250 and the Nissan Frontier have the same basic after-sale protection.