Utility
The Silverado 2500HD is likely a better choice than the Nissan Frontier with respect to transporting cargo, especially if you often need to carry a lot of suitcases or big animals.
Drivers with frequent kid-duty might favor the Chevrolet Silverado 2500HD over the Nissan Frontier.
The Chevrolet Silverado 2500HD outpulls the Nissan Frontier by a sizeable margin.
Performance
In terms of horsepower, the Silverado 2500HD packs quite a wallop and will knock the Frontier down a few rungs. On the other hand, note that high horsepower engines often command higher insurance premiums.
Dimensions
The Chevrolet Silverado 2500HD is tremendously more bulky than the Nissan Frontier.
Your wallet will hurt more every time you fill up the Chevrolet Silverado 2500HD than the Nissan Frontier because of its bigger tank.
The Nissan and the Chevrolet Silverado 2500HD compete for the same parking spaces.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Frontier is considerably cheaper to get to the dealership than the Chevrolet.
As far as MSRP, the Nissan Frontier costs considerably less than the Chevrolet Silverado 2500HD.
Handling
With their similar turning circles, the Nissan Frontier and the Chevrolet most definitely handle about the same into and out of tight spots.
Drivetrain
The Nissan Frontier's engine is tremendously smaller than the Chevrolet's. Note that smaller engines can be stressed more; on the other hand, smaller engines typically get better gas mileage.
Torque is the force that lets you accelerate quickly, and in this respect, the Chevrolet is tremendously more powerful than the Nissan.
Torque equals pickup, and the Silverado 2500HD will have picked up and gone by the time the Nissan finally gets moving.
Comfort
Taller drivers will substantially enjoy the extra head room in the Chevrolet Silverado 2500HD's front cabin compared to the Nissan.
The ampler interior dimensions of the Chevrolet Silverado 2500HD make it significantly roomier for your passengers than the Nissan Frontier.
Warranty
The Chevrolet and the Nissan have the same basic warranty.