Utility
The Mercedes-Benz E-Class's bigger trunk will accommodate more sizeable objects than the Lexus GS 450h.
The Lexus GS 450h and the Mercedes-Benz E-Class can accommodate the same number of passengers.
Performance
With that kind of horsepower, both the Lexus GS 450h and the Mercedes-Benz E-Class are full-blown speedsters.
Dimensions
The Lexus GS 450h is somewhat more ponderous than the Mercedes-Benz E-Class.
Your wallet will hurt more every time you fill up the E-Class than the GS 450h because of its larger tank.
The Lexus GS 450h rides lower than the Mercedes-Benz E-Class, which is a good thing for its center of gravity and ease of access.
The Lexus and the Mercedes-Benz E-Class compete for the same parking spaces.
Convenience
You'll very likely have to take the Mercedes-Benz E-Class for a fill-up more often than the GS 450h because of its tank size and fuel economy.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. It costs roughly the same to get the Lexus GS 450h to the dealership as the E-Class.
The Mercedes-Benz E-Class will tax your gasoline budget tremendously more than the Lexus GS 450h will.
The Lexus GS 450h will save you money at the pump compared to the Mercedes-Benz.
The Mercedes-Benz E-Class isn't much more expensive than the Lexus GS 450h with respect to MSRP.
The Lexus GS 450h isn't much less expensive than the E-Class when it comes to out-the-door price.
The Mercedes-Benz E-Class will cost you a bunch of money in gasoline every year compared to the Lexus GS 450h.
Handling
With their comparable turning circles, the Lexus GS 450h and the Mercedes-Benz E-Class most definitely handle roughly the same into and out of tight spots.
Drivetrain
The Mercedes-Benz E-Class's engine is tremendously larger than the Lexus's. Note that more sizeable engines may use more gas than smaller ones.
Torque equals pickup, and the Mercedes-Benz E-Class will have picked up and gone by the time the Lexus GS 450h finally gets moving.
The Lexus GS 450h could learn a lesson or two from the Mercedes-Benz E-Class when it comes to pickup.
Comfort
Taller drivers will markedly enjoy the extra head room in the E-Class's front cabin compared to the Lexus.
Overview
The Mercedes-Benz E-Class and the Lexus GS 450h have the same basic after-sale protection.