Utility
The GS 450h and the Lexus LS 460 can accommodate the same number of passengers.
Performance
As far as horsepower, the Lexus LS 460 packs quite a punch and will knock the Lexus GS 450h down a few rungs. On the flip side, bear in mind that high horsepower engines often command higher insurance premiums.
Dimensions
Your wallet will hurt more every time you fill up the LS 460 than the GS 450h because of its bigger tank.
The Lexus GS 450h and the LS 460 compete for the same parking spaces.
Convenience
You most definitely won't have to visit your friendly gas station more often with the Lexus GS 450h than with the Lexus LS 460, as both offer similar ranges.
Cost
Producing an accurate gas mileage evaluation is so hard that some think not even the federal government can do it, but it looks as though the Lexus GS 450h is the winner regarding gas mileage.
As far as gas mileage, the Lexus GS 450h and the Lexus LS 460 don't differ much.
With respect to MSRP, the LS 460 costs substantially more than the GS 450h.
Handling
With their comparable turning radii, the Lexus LS 460 and the Lexus GS 450h likely handle approximately the same into and out of tight spots.
Drivetrain
The Lexus LS 460 has a larger engine than the Lexus GS 450h. Note that smaller engines typically get better gas mileage, but smaller engines can be stressed more.
The Lexus GS 450h could learn a lesson or two from the Lexus LS 460 as far as torque.
Torque is roughly equivalent to acceleration, and in this respect, the Lexus LS 460 is considerably more powerful than the Lexus GS 450h.
Comfort
While the front cabin in the Lexus LS 460 offers a bit more head room than the Lexus GS 450h, there honestly isn't much of a difference.
While the rear of the LS 460 offers a bit more head- and leg-room than the Lexus GS 450h, there honestly isn't much of a difference.
Warranty
The Lexus LS 460 and the GS 450h have the same basic warranty.