Cost
Producing a precise gas mileage evaluation is so tricky that some think not even the federal government can do it, but it looks as though the GS 450h is the winner regarding fuel economy.
Regarding MSRP, the Lexus GS 450h costs almost as much as the Lexus GS 460 (though the Lexus GS 460 is a little cheaper).
Utility
The GS 450h and the Lexus GS 460 can accommodate the same number of passengers.
Convenience
You won't have to visit your friendly gas station more often with the Lexus GS 460 than with the Lexus GS 450h, as both offer comparable ranges.
Dimensions
The Lexus GS 450h is considerably more bulky than the Lexus GS 460.
The Lexus GS 450h's tank is approximately the same size as the GS 460's, though the GS 460's is slightly larger.
Handling
With their comparable turning circles, the Lexus GS 460 and the Lexus GS 450h quite certainly handle roughly the same into and out of tight spots.
Drivetrain
The Lexus GS 460 has a bigger engine than the Lexus GS 450h. Remember that smaller engines are often cheaper to fix, but a smaller engine usually has to work a little harder.
The Lexus GS 460 packs quite a wallop compared to the Lexus GS 450h with respect to torque, which is the force that lets you accelerate quickly.
Torque equals pickup, and the Lexus GS 460 will have picked up and gone by the time the Lexus GS 450h finally gets moving.
Warranty
The Lexus GS 460 and the GS 450h have the same basic warranty.