Utility
Neither the Chrysler 300 nor the Lexus ES 350 has a marked advantage as far as seating capacity.
Dimensions
The 300 is considerably heavier than the Lexus.
The Lexus ES 350's tank is almost the same size as the Chrysler 300's, though the Chrysler 300's is slightly larger.
The ES 350 and the 300 compete for the same parking spaces.
The Lexus ES 350's shorter wheelbase will give a more maneuverable feel in daily traffic. On the flip side, the Chrysler 300 is likely to have a smoother, more stable ride.
Convenience
The Chrysler 300's fuel tank will need to be replenished a little more often than the unit in the Lexus ES 350.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The 300 is considerably cheaper to get to the dealership than the Lexus ES 350.
There isn't much of a difference in gas mileage here, but if you must know, the Lexus is a tad more economical than the Chrysler 300.
With respect to fuel economy, the ES 350 has the Chrysler 300 beat.
The 300 isn't much less expensive than the Lexus regarding MSRP.
Handling
With their comparable turning circles, the ES 350 and the Chrysler 300 most definitely handle roughly the same into and out of tight spots.
Drivetrain
The Chrysler's engine isn't much more massive than the Lexus ES 350's.
Comfort
Taller drivers will considerably enjoy the extra head room in the Chrysler 300's front cabin compared to the Lexus ES 350.
The Chrysler 300 provides more head- and leg-room to your passengers than the Lexus ES 350 does.
Warranty
The basic warranty that comes with the Chrysler 300 isn't quite as generous as the Lexus ES 350's.