Drivetrain
The Lexus ES 350's engine is significantly more sizeable than the Buick LaCrosse's. Remember that larger engines may use more gas than smaller ones.
The Buick LaCrosse could learn a lesson or two from the ES 350 when it comes to torque.
Torque is roughly equivalent to acceleration, and in this respect, the Lexus is significantly more powerful than the Buick LaCrosse.
Utility
The Buick and the Lexus ES 350 can accommodate the same number of passengers.
Convenience
The Buick LaCrosse's fuel tank will need to be replenished somewhat more often than the unit in the Lexus ES 350.
Comfort
While the front cabin in the Buick LaCrosse offers a bit more head room than the Lexus ES 350, there honestly isn't much of a difference.
The ampler interior dimensions of the Buick make it substantially roomier for your passengers than the ES 350.
Dimensions
The ES 350's tank is about the same size as the Buick LaCrosse's, though the Buick LaCrosse's is a little bigger.
The ES 350 and the Buick LaCrosse compete for the same parking spaces.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The LaCrosse is significantly cheaper to get to the dealership than the Lexus ES 350.
The ES 350 will save you money at the pump compared to the Buick LaCrosse.
The Buick LaCrosse doesn't pale in comparison to the Lexus ES 350 in terms of fuel economy.
The Buick LaCrosse isn't much less expensive than the Lexus ES 350 as far as MSRP.
Warranty
The Lexus ES 350 and the Buick have the same basic warranty.