Utility
The F-250's larger trunk will accommodate more massive items than the GMC Canyon.
The GMC Canyon and the F-250 can accommodate the same number of passengers.
The F-250 is a better choice than the GMC Canyon as far as hauling capacity, especially if you frequently need to carry a lot of equipment or big animals.
Towing is significantly more the Ford F-250's forte than it is the GMC Canyon's.
Performance
With that kind of horsepower, both the GMC and the Ford F-250 are true sportscars.
Dimensions
The F-250 is tremendously more bulky than the Canyon.
Your wallet will hurt more every time you fill up the Ford F-250 than the GMC Canyon because of its larger tank.
The GMC fits in smaller parking spaces than the F-250.
The GMC Canyon's shorter wheelbase will give a more maneuverable feel in daily traffic. However, the Ford F-250 is likely to have a smoother, more stable ride.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The GMC Canyon is substantially cheaper to get to the dealership than the F-250.
With respect to MSRP, the Ford F-250 costs tremendously more than the GMC Canyon.
Handling
With its tighter turning circle, the GMC Canyon is most certainly sprier than the Ford F-250, something to consider if you do a lot of city driving; however, remember that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The Ford F-250's engine is tremendously larger than the GMC's. Bear in mind that more massive engines may use more gasoline than smaller ones.
The Ford packs quite a punch compared to the GMC Canyon regarding torque, which is roughly equivalent to acceleration.
Torque is roughly equivalent to acceleration, and in this respect, the Ford F-250 is tremendously more powerful than the GMC Canyon.
Comfort
Taller drivers will considerably enjoy the extra head room in the Ford F-250's front cabin compared to the GMC.
The Ford F-250 offers more head- and leg-room to your passengers than the GMC does.
Warranty
The Ford F-250 and the GMC Canyon have the same basic warranty.