Utility
The Nissan Titan and the Ford F-150 can accommodate the same number of passengers.
The Nissan Titan is a better choice than the F-150 in terms of hauling capacity, especially if you often need to carry a lot of gear or big dogs.
The Nissan Titan outpulls the Ford F-150 by a large margin.
Dimensions
Your wallet will hurt more every time you fill up the F-150 than the Nissan because of its larger tank.
The Ford F-150 and the Nissan Titan compete for the same parking spaces.
The Ford F-150's shorter wheelbase will give a more maneuverable feel in daily traffic. However, the Nissan Titan is likely to have a smoother, more stable ride.
Convenience
You'll quite certainly have to take the Nissan for a fill-up more often than the Ford F-150 because of its tank size and gas mileage.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Nissan Titan is considerably cheaper to get to the dealership than the Ford F-150.
As far as gas mileage, the Ford F-150 has the Nissan Titan beat.
The Nissan Titan doesn't pale in comparison to the Ford F-150 regarding gas mileage.
In terms of MSRP, the Nissan Titan costs almost as much as the Ford F-150 (though the Ford F-150 is a little cheaper).
Handling
With its tighter turning radius, the F-150 is most certainly sprier than the Nissan Titan, something to consider if you do a lot of city driving; on the other hand, keep in mind that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The Ford F-150's engine is substantially smaller than the Titan's. Note that a smaller engine usually has to work a little harder; however, smaller engines are often cheaper to fix.
Torque is roughly equivalent to acceleration, and in this respect, the Nissan Titan is considerably more powerful than the Ford F-150.
Torque equals pickup, and the Nissan will have picked up and gone by the time the Ford F-150 finally gets moving.
Comfort
The Ford F-150 is not particularly more spacious for your passengers than the Titan.
Warranty
The Ford F-150 and the Nissan Titan have the same basic warranty.