Handling
With their similar turning circles, the Ford F-150 and the Nissan Frontier definitely handle approximately the same into and out of tight spots.
Drivetrain
The Ford F-150 has a more sizeable engine than the Nissan Frontier. Note that smaller engines are often cheaper to fix, but a smaller engine usually has to work a little harder.
The Nissan Frontier could learn a lesson or two from the F-150 in terms of pickup.
The Ford packs quite a wallop compared to the Nissan Frontier with respect to torque, which is roughly equivalent to acceleration.
Utility
The Ford F-150 is likely a better choice than the Nissan Frontier regarding hauling capacity, especially if you frequently need to carry a lot of loot or big animals.
The Ford will quite certainly prove handier than the Nissan for those of you with frequent child-cargo.
Convenience
You will most definitely have to visit your friendly gas station more often with the Nissan Frontier than with the F-150.
Comfort
Taller drivers will considerably enjoy the extra head room in the Ford F-150's front cabin compared to the Nissan Frontier.
The Ford F-150 offers more head- and leg-room to your passengers than the Nissan Frontier does.
Dimensions
The Ford F-150 is significantly heavier than the Nissan Frontier.
Your wallet will hurt more every time you fill up the F-150 than the Nissan because of its bigger tank.
The Nissan Frontier and the Ford F-150 compete for the same parking spaces.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Nissan is considerably cheaper to get to the dealership than the Ford F-150.
The F-150 won't tax your gasoline budget considerably more than the Nissan will.
The Nissan Frontier won't save you much money at the pump compared to the F-150.
As far as MSRP, the Nissan Frontier costs considerably less than the Ford F-150.
Warranty
The Ford F-150 and the Nissan Frontier have the same basic after-sale protection.