Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. It costs about the same to get the Ford F-150 to the dealership as the GMC Sierra 3500HD.
The Ford F-150 is substantially less expensive than the GMC with respect to MSRP.
Utility
The Sierra 3500HD is a better choice than the Ford F-150 with respect to transporting cargo, especially if you often need to carry a lot of gear or large animals.
Neither the GMC nor the F-150 has a marked advantage regarding seating capacity.
Towing is considerably more the Sierra 3500HD's forte than it is the Ford F-150's.
Comfort
While the front cabin in the GMC Sierra 3500HD offers a bit more head room than the Ford F-150, there honestly isn't much of a difference.
While the rear of the GMC provides a bit more head- and leg-room than the Ford F-150, there really isn't much of a difference.
Dimensions
The GMC Sierra 3500HD is tremendously more bulky than the Ford.
The GMC Sierra 3500HD's tank is approximately the same size as the Ford's, though the Ford F-150's is slightly larger.
The Ford F-150 and the GMC Sierra 3500HD compete for the same parking spaces.
Handling
With its tighter turning circle, the Ford is definitely nimbler than the GMC Sierra 3500HD, something to consider if you do a lot of city driving; on the other hand, bear in mind that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The GMC's engine is considerably bigger than the Ford F-150's. Bear in mind that larger engines may use more gasoline than smaller ones.
The F-150 could learn a lesson or two from the Sierra 3500HD in terms of pickup.
The GMC Sierra 3500HD packs quite a punch compared to the Ford F-150 with respect to torque, which is roughly equivalent to acceleration.
Warranty
The F-150 and the GMC Sierra 3500HD have the same basic after-sale protection.