Handling
With its tighter turning radius, the F-150 is quite certainly more maneuverable than the GMC Sierra 2500HD, something to consider if you do a lot of city driving; on the flip side, keep in mind that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The F-150's engine is significantly smaller than the GMC Sierra 2500HD's. Bear in mind that smaller engines can be stressed more; on the flip side, smaller engines are often cheaper to fix.
The Ford F-150 could learn a lesson or two from the GMC Sierra 2500HD with respect to pickup.
The Sierra 2500HD packs quite a wallop compared to the F-150 in terms of torque, which is roughly equivalent to acceleration.
Utility
There's no clear winner between the Ford F-150 and the GMC Sierra 2500HD in terms of transporting cargo.
The GMC Sierra 2500HD and the Ford F-150 can accommodate the same number of passengers.
The GMC Sierra 2500HD is a better choice than the F-150 when it comes to hauling capacity, especially if you frequently need to carry a lot of luggage or big dogs.
The GMC outpulls the F-150 by a massive margin.
Comfort
While the front cabin in the GMC Sierra 2500HD offers a bit more head room than the Ford F-150, there really isn't much of a difference.
While the rear of the GMC Sierra 2500HD offers a bit more head- and leg-room than the F-150, there really isn't much of a difference.
Dimensions
The Sierra 2500HD is considerably more bulky than the Ford F-150.
Your wallet will hurt more every time you fill up the F-150 than the GMC Sierra 2500HD because of its larger tank.
The Ford F-150 and the Sierra 2500HD compete for the same parking spaces.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. It costs about the same to get the F-150 to the dealership as the GMC Sierra 2500HD.
As far as MSRP, the Ford F-150 costs significantly less than the GMC Sierra 2500HD.
Warranty
The Ford F-150 and the Sierra 2500HD have the same basic after-sale protection.