Performance
When it comes to horsepower, the Ford E-350 Super Duty packs quite a wallop and will knock the Sprinter Wagon 2500 down a few rungs. However, keep in mind that high horsepower engines often command higher insurance premiums.
Handling
With their similar turning circles, the Dodge Sprinter Wagon 2500 and the E-350 Super Duty most certainly handle almost the same into and out of tight spots.
Drivetrain
The Ford E-350 Super Duty has a more massive engine than the Dodge Sprinter Wagon 2500. Keep in mind that smaller engines typically get better gas mileage, but smaller engines can be stressed more.
Utility
The Dodge will most definitely prove more practical than the Ford for those of you with frequent kid-cargo.
The Ford E-350 Super Duty is a better choice than the Sprinter Wagon 2500 with respect to hauling capacity, especially if you often need to carry a lot of equipment or sizeable animals.
The Ford outpulls the Sprinter Wagon 2500 by a massive margin.
Dimensions
Your wallet will hurt more every time you fill up the E-350 Super Duty than the Sprinter Wagon 2500 because of its larger tank.
The Ford E-350 Super Duty and the Dodge compete for the same parking spaces.
Cost
The Ford E-350 Super Duty is tremendously less expensive than the Dodge Sprinter Wagon 2500 in terms of MSRP.
Warranty
The Ford E-350 Super Duty and the Dodge Sprinter Wagon 2500 have the same basic after-sale protection.