Cost
The Dodge is tremendously pricier than the E-250 as far as MSRP.
Utility
The Dodge Sprinter Wagon 2500 will most definitely prove handier than the Ford E-250 for those of you with frequent kid-cargo.
The E-250 is a better choice than the Dodge Sprinter Wagon 2500 when it comes to hauling capacity, especially if you frequently need to carry a lot of equipment or large animals.
Towing is significantly more the Ford E-250's forte than it is the Dodge Sprinter Wagon 2500's.
Dimensions
Your wallet will hurt more every time you fill up the Ford E-250 than the Dodge Sprinter Wagon 2500 because of its bigger tank.
The Ford E-250 and the Sprinter Wagon 2500 compete for the same parking spaces.
Performance
As far as horsepower, the Ford packs quite a punch and will knock the Dodge Sprinter Wagon 2500 down a few rungs. On the other hand, remember that high horsepower engines often command higher insurance premiums.
Handling
With their similar turning radii, the Dodge Sprinter Wagon 2500 and the Ford E-250 likely handle approximately the same into and out of tight spots.
Drivetrain
The Ford's engine is tremendously bigger than the Dodge Sprinter Wagon 2500's. Bear in mind that more sizeable engines may use more gasoline than smaller ones.
Torque is roughly equivalent to acceleration, and in this respect, the E-250 isn't much more powerful than the Dodge Sprinter Wagon 2500.
Warranty
The Dodge Sprinter Wagon 2500 and the E-250 have the same basic warranty.