Performance
As far as horsepower, the E-150 packs quite a punch and will knock the Dodge Sprinter Wagon 2500 down a few rungs. On the flip side, note that high horsepower engines often command higher insurance premiums.
Handling
With their comparable turning circles, the Sprinter Wagon 2500 and the Ford E-150 most definitely handle approximately the same into and out of tight spots.
Drivetrain
The Ford E-150 has a bigger engine than the Dodge Sprinter Wagon 2500. Note that smaller engines typically get better gas mileage, but a smaller engine usually has to work a little harder.
The Dodge Sprinter Wagon 2500 has no lessons to learn in terms of torque from the Ford E-150.
Utility
The Dodge will definitely prove handier than the Ford E-150 for those of you with frequent child-cargo.
There's no clear winner between the Ford and the Sprinter Wagon 2500 with respect to transporting cargo.
Towing is substantially more the E-150's forte than it is the Dodge Sprinter Wagon 2500's.
Dimensions
Your wallet will hurt more every time you fill up the E-150 than the Dodge Sprinter Wagon 2500 because of its larger tank.
The Ford E-150 and the Dodge Sprinter Wagon 2500 compete for the same parking spaces.
Cost
The Dodge Sprinter Wagon 2500 is tremendously more expensive than the E-150 regarding MSRP.
Warranty
The Sprinter Wagon 2500 and the Ford E-150 have the same basic warranty.