Utility
Drivers with frequent kid-duty might favor the Honda Odyssey over the Sprinter Van 3500.
The Dodge Sprinter Van 3500 is a better choice than the Honda in terms of transporting cargo, especially if you often need to carry a lot of cargo or large pets.
The Dodge Sprinter Van 3500 outpulls the Honda Odyssey by a sizeable margin.
Performance
With respect to horsepower, the Honda Odyssey packs quite a wallop and will knock the Dodge Sprinter Van 3500 down a few rungs. On the other hand, keep in mind that high horsepower engines often command higher insurance premiums.
Dimensions
The Sprinter Van 3500 is substantially more bulky than the Honda Odyssey.
Your wallet will hurt more every time you fill up the Dodge Sprinter Van 3500 than the Honda Odyssey because of its larger tank.
The Odyssey fits in smaller parking spaces than the Dodge.
The Honda Odyssey's shorter wheelbase may produce a less-settled highway ride but a more maneuverable feel in daily traffic than the Dodge Sprinter Van 3500.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. The Honda is significantly cheaper to get to the dealership than the Dodge Sprinter Van 3500.
Regarding MSRP, the Dodge Sprinter Van 3500 costs significantly more than the Honda Odyssey.
Handling
With its tighter turning circle, the Honda Odyssey is quite certainly nimbler than the Sprinter Van 3500, something to consider if you do a lot of city driving; on the other hand, remember that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The Honda Odyssey has a more massive engine than the Dodge Sprinter Van 3500. Bear in mind that smaller engines are often cheaper to fix, but smaller engines can be stressed more.
Torque equals pickup, and the Dodge Sprinter Van 3500 will have picked up and gone by the time the Odyssey finally gets moving.
Warranty
The Dodge Sprinter Van 3500 and the Honda Odyssey have the same basic warranty.