Performance
With that kind of horsepower, the GMC Savana 3500 is a true speedster.
Handling
With their similar turning circles, the Dodge Sprinter Van 3500 and the Savana 3500 most certainly handle almost the same into and out of tight spots.
Drivetrain
The Dodge Sprinter Van 3500's engine is tremendously smaller than the GMC Savana 3500's. Bear in mind that smaller engines can be stressed more; on the flip side, smaller engines typically get better gas mileage.
The Sprinter Van 3500 could learn a lesson or two from the GMC as far as pickup.
Torque is the force that lets you accelerate quickly, and in this respect, the GMC Savana 3500 is considerably more powerful than the Dodge Sprinter Van 3500.
Utility
The GMC Savana 3500 will most definitely prove more convenient than the Dodge Sprinter Van 3500 for those of you with frequent kid-cargo.
The Sprinter Van 3500 is likely a better choice than the GMC Savana 3500 in terms of hauling capacity, especially if you often need to carry a lot of equipment or massive pets.
There's little the GMC Savana 3500 can tow that the Dodge Sprinter Van 3500 cannot.
Dimensions
The GMC Savana 3500 is substantially heavier than the Dodge Sprinter Van 3500.
Your wallet will hurt more every time you fill up the GMC than the Dodge Sprinter Van 3500 because of its larger tank.
The GMC Savana 3500 and the Dodge Sprinter Van 3500 compete for the same parking spaces.
The GMC's shorter wheelbase will give a more maneuverable feel in daily traffic. However, the Sprinter Van 3500 is likely to have a smoother, more stable ride.
Cost
As far as MSRP, the Savana 3500 costs significantly less than the Dodge Sprinter Van 3500.
Warranty
The GMC Savana 3500 and the Dodge Sprinter Van 3500 have the same basic warranty.