Cost
The GMC Savana 2500 is tremendously less expensive than the Dodge Sprinter Van 3500 with respect to MSRP.
Utility
The GMC Savana 2500 will most definitely prove friendlier than the Dodge Sprinter Van 3500 for those of you with frequent child-cargo.
The Dodge Sprinter Van 3500 is likely a better choice than the Savana 2500 when it comes to transporting cargo, especially if you frequently need to carry a lot of loot or sizeable pets.
There's little the GMC Savana 2500 can tow that the Dodge Sprinter Van 3500 cannot.
Dimensions
Your wallet will hurt more every time you fill up the GMC than the Dodge Sprinter Van 3500 because of its larger tank.
The GMC Savana 2500 and the Dodge Sprinter Van 3500 compete for the same parking spaces.
The Dodge Sprinter Van 3500's longer wheelbase will likely result in a smoother, more stable ride; on the other hand, the Savana 2500 may give a more maneuverable feel in daily traffic.
Performance
With that kind of horsepower, the GMC Savana 2500 is a true sports car.
Handling
With their similar turning circles, the Sprinter Van 3500 and the GMC Savana 2500 most definitely handle almost the same into and out of tight spots.
Drivetrain
The GMC Savana 2500's engine is tremendously larger than the Dodge Sprinter Van 3500's. Keep in mind that more massive engines may use more gasoline than smaller ones.
Torque is roughly equivalent to acceleration, and in this respect, the GMC is significantly more powerful than the Dodge Sprinter Van 3500.
The Savana 2500 packs quite a wallop compared to the Dodge Sprinter Van 3500 in terms of torque, which is the force that lets you accelerate quickly.
Warranty
The GMC Savana 2500 and the Dodge Sprinter Van 3500 have the same basic warranty.