Performance
As far as horsepower, the E-250 packs quite a wallop and will knock the Dodge Sprinter Van 3500 down a few rungs. However, keep in mind that high horsepower engines often command higher insurance premiums.
Handling
With their similar turning radii, the Dodge Sprinter Van 3500 and the Ford most definitely handle approximately the same into and out of tight spots.
Drivetrain
The Ford's engine is tremendously larger than the Dodge Sprinter Van 3500's. Remember that bigger engines may use more gas than smaller ones.
Torque is roughly equivalent to acceleration, and in this respect, the Ford isn't much more powerful than the Dodge Sprinter Van 3500.
Utility
The Dodge Sprinter Van 3500 will most definitely prove more convenient than the Ford E-250 for those of you with frequent child-cargo.
The Dodge Sprinter Van 3500 is likely a better choice than the Ford E-250 as far as hauling capacity, especially if you frequently need to carry a lot of suitcases or large pets.
Towing is substantially more the Dodge Sprinter Van 3500's forte than it is the Ford E-250's.
Dimensions
Your wallet will hurt more every time you fill up the Ford E-250 than the Dodge Sprinter Van 3500 because of its larger tank.
The E-250 and the Dodge Sprinter Van 3500 compete for the same parking spaces.
Cost
With respect to MSRP, the Dodge Sprinter Van 3500 costs tremendously more than the Ford E-250.
Warranty
The Dodge Sprinter Van 3500 and the Ford E-250 have the same basic warranty.