Performance
In terms of horsepower, the Ford E-150 packs quite a punch and will knock the Dodge down a few rungs. On the flip side, note that high horsepower engines often command higher insurance premiums.
Handling
With their similar turning circles, the Dodge and the Ford E-150 most definitely handle approximately the same into and out of tight spots.
Drivetrain
The Ford E-150's engine is tremendously larger than the Dodge Sprinter Van 3500's. Note that bigger engines may use more gas than smaller ones.
Torque is the force that lets you accelerate quickly, and in this respect, the Ford E-150 isn't much more powerful than the Dodge.
Utility
Drivers with frequent child-duty might favor the Ford over the Dodge Sprinter Van 3500.
The Dodge Sprinter Van 3500 is a better choice than the Ford as far as hauling capacity, especially if you frequently need to carry a lot of stuff or big animals.
The Dodge Sprinter Van 3500 outpulls the E-150 by a massive margin.
Dimensions
Your wallet will hurt more every time you fill up the Ford than the Dodge Sprinter Van 3500 because of its bigger tank.
The Ford and the Dodge Sprinter Van 3500 compete for the same parking spaces.
Cost
With respect to MSRP, the Ford E-150 costs tremendously less than the Dodge.
Warranty
The Dodge Sprinter Van 3500 and the Ford E-150 have the same basic warranty.