Cost
The Dodge Sprinter Van 2500 is substantially more expensive than the Ford E-350 Super Duty with respect to MSRP.
Utility
Drivers with frequent child-duty might favor the Dodge Sprinter Van 2500 over the E-350 Super Duty.
The Ford E-350 Super Duty is likely a better choice than the Dodge Sprinter Van 2500 with respect to hauling capacity, especially if you frequently need to carry a lot of equipment or large animals.
Towing is substantially more the Ford's forte than it is the Dodge's.
Dimensions
The Ford E-350 Super Duty is substantially more bulky than the Dodge Sprinter Van 2500.
Your wallet will hurt more every time you fill up the Ford E-350 Super Duty than the Sprinter Van 2500 because of its bigger tank.
The Ford E-350 Super Duty and the Dodge Sprinter Van 2500 compete for the same parking spaces.
Performance
When it comes to horsepower, the Ford E-350 Super Duty packs quite a wallop and will knock the Dodge Sprinter Van 2500 down a few rungs. However, bear in mind that high horsepower engines often command higher insurance premiums.
With that kind of horsepower, the Ford E-350 Super Duty is a legitimate speedster.
Handling
With their similar turning radii, the Dodge Sprinter Van 2500 and the Ford E-350 Super Duty quite certainly handle almost the same into and out of tight spots.
Drivetrain
The Ford's engine is tremendously larger than the Dodge's. Remember that more massive engines may use more gasoline than smaller ones.
Torque is the force that lets you accelerate quickly, and in this respect, the E-350 Super Duty is substantially more powerful than the Sprinter Van 2500.
Warranty
The Ford E-350 Super Duty and the Dodge Sprinter Van 2500 have the same basic after-sale protection.