Performance
Regarding horsepower, the Ford E-150 packs quite a punch and will knock the Dodge Sprinter Van 2500 down a few rungs. On the other hand, bear in mind that high horsepower engines often command higher insurance premiums.
Handling
With their similar turning radii, the Dodge Sprinter Van 2500 and the Ford E-150 definitely handle approximately the same into and out of tight spots.
Drivetrain
The Ford E-150 has a more massive engine than the Dodge Sprinter Van 2500. Note that smaller engines are often cheaper to fix, but a smaller engine usually has to work a little harder.
The Sprinter Van 2500 has no lessons to learn with respect to torque from the Ford E-150.
Utility
Drivers with frequent child-duty might favor the Ford over the Dodge.
The Dodge Sprinter Van 2500 is a better choice than the Ford E-150 when it comes to transporting cargo, especially if you often need to carry a lot of luggage or massive pets.
The Ford E-150 outpulls the Dodge Sprinter Van 2500 by a big margin.
Dimensions
The Ford E-150 is significantly more bulky than the Dodge Sprinter Van 2500.
Your wallet will hurt more every time you fill up the Ford E-150 than the Sprinter Van 2500 because of its larger tank.
The Ford E-150 and the Dodge Sprinter Van 2500 compete for the same parking spaces.
Cost
The Sprinter Van 2500 is tremendously costlier than the Ford with respect to MSRP.
Warranty
The Sprinter Van 2500 and the Ford E-150 have the same basic warranty.