Utility
There's no obvious winner between the GMC Sierra 2500HD and the Dodge Ram 3500 with respect to transporting cargo.
Neither the Dodge Ram 3500 nor the GMC Sierra 2500HD has a marked advantage regarding seating capacity.
The GMC is likely a better choice than the Dodge as far as transporting cargo, especially if you often need to carry a lot of luggage or large pets.
Performance
With that kind of horsepower, both the Dodge Ram 3500 and the Sierra 2500HD are true speedsters.
Dimensions
The Dodge is substantially more bulky than the Sierra 2500HD.
Your wallet will hurt more every time you fill up the Dodge Ram 3500 than the GMC because of its bigger tank.
The GMC and the Dodge Ram 3500 compete for the same parking spaces.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. It costs approximately the same to get the Dodge to the dealership as the GMC Sierra 2500HD.
The GMC is significantly less expensive than the Dodge Ram 3500 regarding MSRP.
Handling
With their similar turning radii, the Dodge Ram 3500 and the GMC Sierra 2500HD most definitely handle approximately the same into and out of tight spots.
Drivetrain
The Sierra 2500HD's engine is a bit smaller than the Dodge Ram 3500's, but not terribly so.
The Dodge Ram 3500 has no lessons to learn when it comes to pickup from the Sierra 2500HD.
Comfort
While the front cabin in the GMC Sierra 2500HD offers a bit more head room than the Ram 3500, there really isn't much of a difference.
The Dodge Ram 3500 provides more head- and leg-room to your passengers than the GMC Sierra 2500HD does.
Warranty
The GMC Sierra 2500HD and the Dodge Ram 3500 have the same basic warranty.