Performance
With that kind of horsepower, both the Silverado 1500 and the Silverado 2500HD are legitimate sportscars.
Handling
With its tighter turning circle, the Chevrolet Silverado 1500 is most certainly more agile than the Chevrolet Silverado 2500HD, something to consider if you do a lot of city driving; on the other hand, keep in mind that a vehicle with a tight turning circle may feel a bit twitchy on the highway.
Drivetrain
The Silverado 2500HD's engine is substantially more sizeable than the Chevrolet Silverado 1500's. Remember that more massive engines may use more gas than smaller ones.
Torque is the force that lets you accelerate quickly, and in this respect, the Chevrolet Silverado 2500HD is significantly more powerful than the Chevrolet Silverado 1500.
Utility
The Chevrolet Silverado 2500HD's more sizeable trunk will accommodate more sizeable items than the Chevrolet Silverado 1500.
The Chevrolet Silverado 1500 and the Chevrolet Silverado 2500HD can accommodate the same number of passengers.
The Chevrolet Silverado 2500HD is a better choice than the Chevrolet Silverado 1500 as far as hauling capacity, especially if you often need to carry a lot of equipment or big animals.
Towing is considerably more the Silverado 2500HD's forte than it is the Silverado 1500's.
Comfort
While the front cabin in the Chevrolet Silverado 1500 offers a bit more head room than the Chevrolet Silverado 2500HD, there really isn't much of a difference.
The Chevrolet Silverado 2500HD is not particularly more spacious for your passengers than the Chevrolet Silverado 1500.
Dimensions
The Silverado 2500HD is significantly heavier than the Chevrolet Silverado 1500.
The Chevrolet Silverado 1500 and the Chevrolet Silverado 2500HD compete for the same parking spaces.
The Chevrolet Silverado 1500's shorter wheelbase will likely give a more agile feel in daily traffic. On the flip side, the Chevrolet Silverado 2500HD is likely to have a smoother, more stable ride.
Cost
In terms of MSRP, the Chevrolet Silverado 1500 costs substantially less than the Chevrolet Silverado 2500HD.
Warranty
The Chevrolet Silverado 2500HD and the Chevrolet Silverado 1500 have the same basic after-sale protection.