Utility
The Mercedes-Benz E-Class's more sizeable trunk will accommodate more large items than the Cadillac STS.
Neither the Cadillac STS nor the Mercedes-Benz E-Class has a marked advantage as far as seating capacity.
Dimensions
Your wallet will hurt more every time you fill up the Mercedes-Benz than the Cadillac STS because of its more capacious tank.
The Mercedes-Benz and the Cadillac STS compete for the same parking spaces.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. It costs roughly the same to get the Cadillac to the dealership as the Mercedes-Benz E-Class.
The Cadillac STS isn't much less costly than the E-Class as far as MSRP.
Handling
The Cadillac STS and the Mercedes-Benz E-Class have approximately similar tires.
With their comparable turning circles, the Mercedes-Benz E-Class and the Cadillac STS definitely handle approximately the same into and out of tight spots.
Drivetrain
The Cadillac STS has a more massive engine than the Mercedes-Benz. Note that smaller engines typically get better gas mileage, but smaller engines can be stressed more.
The Mercedes-Benz E-Class could learn a lesson or two from the Cadillac regarding pickup.
Comfort
While the front cabin in the Mercedes-Benz E-Class offers a bit more head room than the Cadillac STS, there honestly isn't much of a difference.
The Cadillac STS offers more head- and leg-room to your passengers than the Mercedes-Benz E-Class does.
Overview
The E-Class and the Cadillac have the same basic after-sale protection.
When it comes to after-sale protection against corrosion, the Cadillac STS has tremendously better coverage than the Mercedes-Benz.