Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. It costs roughly the same to get the Cadillac STS to the dealership as the Lexus LS 460.
There frankly isn't much of a difference in gas mileage here, but if you must know, the STS is slightly more economical than the Lexus LS 460.
The Cadillac STS won't save you much money at the pump compared to the Lexus LS 460.
The Lexus is substantially costlier than the Cadillac STS with respect to MSRP.
Utility
The Cadillac STS and the Lexus can accommodate the same number of passengers.
Convenience
You'll definitely have to take the Cadillac STS for a fill-up more often than the Lexus LS 460 because of its tank size and fuel economy.
Comfort
While the front cabin in the Cadillac STS offers a bit more head room than the Lexus LS 460, there really isn't much of a difference.
The Cadillac STS offers more head- and leg-room to your passengers than the Lexus LS 460 does.
Dimensions
The Lexus LS 460 is considerably heavier than the STS.
Your wallet will hurt more every time you fill up the Lexus LS 460 than the Cadillac STS because of its bigger tank.
The Cadillac STS and the Lexus LS 460 compete for the same parking spaces.
Performance
Regarding horsepower, the Lexus LS 460 packs quite a punch and will knock the Cadillac STS down a few rungs. On the other hand, keep in mind that high horsepower engines often command higher insurance premiums.
With that kind of horsepower, both the Cadillac STS and the Lexus LS 460 are legitimate speedsters.
Handling
With their comparable turning radii, the Lexus LS 460 and the Cadillac STS likely handle roughly the same into and out of tight spots.
Drivetrain
The Lexus LS 460 has a larger engine than the STS. Keep in mind that smaller engines are often cheaper to fix, but smaller engines can be stressed more.
The Cadillac STS could learn a lesson or two from the Lexus LS 460 as far as pickup.
Torque is the force that lets you accelerate quickly, and in this respect, the Lexus LS 460 is considerably more powerful than the Cadillac STS.
Warranty
The Lexus LS 460 and the STS have the same basic warranty.