Cost
The Cadillac STS will save you money at the pump compared to the Audi S6.
The Audi S6 guzzles a lot of gas compared to the STS.
The Cadillac STS is significantly less expensive than the Audi S6 in terms of MSRP.
The Audi S6 will cost you a bundle in gasoline every year compared to the Cadillac STS.
The Cadillac STS will save you a lots_of_money at the pump every year compared to the Audi.
Utility
Neither the Cadillac STS nor the Audi S6 has a marked advantage as far as seating capacity.
Convenience
You'll likely take the Audi for a fill-up almost as often as the Cadillac.
Comfort
Taller drivers will significantly enjoy the extra head room in the Cadillac STS's front cabin compared to the Audi S6.
While the rear of the Cadillac STS provides a bit more head- and leg-room than the Audi S6, there really isn't much of a difference.
Dimensions
The Audi S6 is considerably more bulky than the Cadillac.
Your wallet will hurt more every time you fill up the S6 than the STS because of its bigger tank.
The S6 and the Cadillac compete for the same parking spaces.
Performance
With that kind of horsepower, both the Cadillac and the Audi S6 are true sportscars.
Handling
With their comparable turning radii, the Cadillac STS and the Audi S6 most certainly handle roughly the same into and out of tight spots.
Drivetrain
The Audi S6 has a more sizeable engine than the Cadillac STS. Bear in mind that smaller engines typically get better gas mileage, but smaller engines can be stressed more.
Torque equals pickup, and the Audi S6 will have picked up and gone by the time the Cadillac STS finally gets moving.
The Cadillac could learn a lesson or two from the S6 regarding pickup.
Warranty
The Audi S6 and the Cadillac STS have the same basic warranty.