Handling
With their comparable turning circles, the Cadillac and the Audi S4 most certainly handle roughly the same into and out of tight spots.
Drivetrain
The Audi S4's engine is significantly smaller than the Cadillac STS's. Bear in mind that a smaller engine usually has to work a little harder; on the flip side, smaller engines typically get better gas mileage.
The Cadillac could learn a lesson or two from the S4 as far as torque.
Utility
Neither the Cadillac STS nor the Audi S4 has a marked advantage when it comes to seating capacity.
Convenience
You most certainly won't have to visit your friendly gas station more often with the Audi S4 than with the Cadillac STS, as both offer comparable mileage ranges.
Comfort
Taller drivers will considerably enjoy the extra head room in the Audi S4's front cabin compared to the Cadillac STS.
Dimensions
The Audi S4's tank is about the same size as the Cadillac STS's, though the Cadillac STS's is slightly bigger.
The Audi S4 and the Cadillac STS compete for the same parking spaces.
Cost
In terms of MSRP, the Audi S4 costs considerably less than the STS.
Warranty
The Audi S4 and the STS have the same basic after-sale protection.