Utility
Drivers with frequent child-duty might favor the Buick Enclave over the Lexus RX 350.
Dimensions
Your wallet will hurt more every time you fill up the Buick than the Lexus because of its bigger tank.
The Lexus and the Buick Enclave compete for the same parking spaces.
The Lexus RX 350's shorter wheelbase may produce a less-settled highway ride but a more maneuverable feel in daily traffic than the Buick.
Convenience
The Lexus RX 350's fuel tank will need to be replenished a tad more often than the unit in the Enclave.
Cost
The destination charge is a standard charge for transporting the vehicle from its point of origin to the dealer. It costs roughly the same to get the Buick Enclave to the dealership as the Lexus RX 350.
The Lexus RX 350 won't save you much money at the pump compared to the Enclave.
With respect to fuel economy, the Lexus RX 350 and the Buick Enclave don't differ much.
The Buick Enclave isn't much pricier than the Lexus RX 350 when it comes to MSRP.
Handling
With their comparable turning circles, the Lexus and the Enclave definitely handle roughly the same into and out of tight spots.
Drivetrain
The Lexus RX 350's engine is slightly smaller than the Enclave's, but not terribly so.
The Lexus RX 350 has no lessons to learn in terms of pickup from the Buick.
Comfort
Taller drivers will significantly enjoy the extra head room in the Buick Enclave's front cabin compared to the Lexus RX 350.
While the rear of the Buick Enclave offers a bit more head- and leg-room than the Lexus, there really isn't much of a difference.
Warranty
The Buick Enclave and the Lexus RX 350 have the same basic warranty.