Performance
Regarding horsepower, the Audi S4 packs quite a wallop and will knock the A6 down a few rungs. However, keep in mind that high horsepower engines often command higher insurance premiums.
Handling
The Audi A6 and the Audi S4 have roughly similar tires.
With their similar turning radiuses, the S4 and the Audi A6 doubtless handle approximately the same into and out of tight spots.
Drivetrain
The Audi S4's engine is markedly larger than the Audi A6's. Keep in mind that more massive engines may use more gasoline than smaller ones.
Torque equals pickup, and the Audi S4 will have picked up and gone by the time the Audi A6 finally gets moving.
Utility
Neither the Audi A6 nor the Audi S4 has a marked advantage regarding seating capacity.
Convenience
You'll quite certainly have to take the S4 for a fill-up more often than the Audi A6 because of its tank size and gas mileage.
Comfort
While the front cabin in the Audi S4 offers a bit more head room than the A6, there honestly isn't much of a difference.
The ampler interior dimensions of the A6 make it markedly roomier for your passengers than the Audi S4.
Dimensions
The Audi A6 is somewhat more ponderous than the S4.
Your wallet will hurt more every time you fill up the Audi A6 than the S4 because of its bigger tank.
The Audi A6 rides lower than the S4, which is a good thing for its center of gravity and ease of access.
The Audi S4 and the A6 compete for the same parking spaces.
The S4's shorter wheelbase will give a more maneuverable feel in daily traffic. On the other hand, the A6 is likely to have a smoother, more stable ride.
Cost
The Audi S4 requires a lot of gas compared to the Audi A6.
In terms of MSRP, the Audi A6 doesn't cost much less than the S4.
Overview
The S4 and the Audi A6 have the same basic after-sale protection.
Other
The A6 produces fewer smog-forming pollutants per 15,000 miles than the Audi S4.